hrp0082p1-d1-111 | Fat Metabolism & Obesity | ESPE2014

A Multiplatform Non-targeted Metabolomics Approach to Investigate Insulin Resistance Associated to Obesity in Childhood

Mastrangelo Annalaura , Martos-Moreno Gabriel , Garcia Antonia , Ruperez Francisco , Chowen Julie , Perez-Jurado Luis , Barbas Coral , Argente Jesus

Background: Childhood obesity is often associated with insulin resistance (IR), which is a key risk factor for the development of comorbidities. The etiologic relation between insulin resistance and obesity is still not completely understood.Objective: In this study a multiplatform metabolomics approach was applied for the first time to elucidate the metabolic alterations in obese children with or without IR. Metabolomics is the revolutionary strategy of...